I shall discuss about the 2nd stage of Virus life cycle, which is the replication of genome, mRNA production, processing and translation. In short, it is known as Viral Replication & Expression.
In actual fact, the way the virus reproduces itself in the host depends on the nature of their respective genome.
For example, Group I of the Baltimore’s Classification - Double stranded DNA viruses (E.G. Smallpox and other viruses from the family Poxviridae), can only replicates in the host cell’s cytoplasm and require host cell polymerases to replicate its genome and therefore is very dependent on the host cell’s cycle and mechanisms. The viral genome contains all factors for genome replication and transcription.
Below is a diagram that describes replication of the genome.
A side note...
Remember Baltimore’s Classification? In studying the subject of viral replication & expression, this classification is important as it is the classification which identifies virus into groups based on their genome & how it is being replicated. This, in turn, gives us a shortcut method of determining how a particular virus replicates as long as we know which class is the virus from.
I realise this after I went back to revise the lecture about viral replication & expression. I also concluded that everything taught to us in the MicroB lectures have significant connection to all the other different aspects in virology. In this case, for example, the Baltimore’s classification can be use to simplify the method which is use to determine how certain type of viruses replicates.
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